Polymyxin B-modified conjugated oligomer nanoparticle for targeted identification and enhanced photodynamic antimicrobial therapy

Qi Jiang; Xinrong Yan; Dan Jiao; Jiangyan Zhang; Yonggang Wu; Yongqiang Cheng

doi:10.1039/d1cc04389g

Polymyxin B-modified conjugated oligomer nanoparticle for targeted identification and enhanced photodynamic antimicrobial therapy

Chem Commun (Camb). 2021 Oct 26;57(85):11244-11247. doi: 10.1039/d1cc04389g.

Authors

Qi Jiang¹, Xinrong Yan¹, Dan Jiao¹, Jiangyan Zhang¹, Yonggang Wu¹, Yongqiang Cheng¹

Affiliation

¹ Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. yqcheng@hbu.edu.cn.

PMID: 34633009
DOI: 10.1039/d1cc04389g

Abstract

We report a photosensitive polymyxin B-modified conjugated oligomer nanoparticle that integrates the targeted identification and synergistic photodynamic therapy in one treatment against resistant Gram-negative bacteria. The study expands the application of antibiotics and opens a new avenue for enhancing photodynamic antimicrobial therapy and fighting bacterial resistance.

MeSH terms

Animals
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Azides / chemistry
Click Chemistry
Drug Resistance, Multiple, Bacterial
Drug Synergism
Escherichia coli / drug effects
Fluorescent Dyes / chemistry
Humans
Mice
Microbial Sensitivity Tests
Nanoparticles / chemistry*
Optical Imaging
Photochemotherapy
Polyethylene Glycols / chemistry*
Polymyxin B / chemistry*
Polymyxin B / pharmacology
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Azides
Fluorescent Dyes
Polyethylene Glycols
Polymyxin B