Multiplex Biosensing for Simultaneous Detection of Mutations in SARS-CoV-2

Hui Xi; Hanlin Jiang; Mario Juhas; Yang Zhang

doi:10.1021/acsomega.1c04024

Multiplex Biosensing for Simultaneous Detection of Mutations in SARS-CoV-2

ACS Omega. 2021 Sep 28;6(40):25846-25859. doi: 10.1021/acsomega.1c04024. eCollection 2021 Oct 12.

Authors

Hui Xi¹, Hanlin Jiang¹, Mario Juhas², Yang Zhang¹

Affiliations

¹ College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China.
² Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Fribourg CH-1700, Switzerland.

Abstract

COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has become the world's largest public health emergency of the past few decades. Thousands of mutations were identified in the SARS-CoV-2 genome. Some mutants are more infectious and may replace the original strains. Recently, B.1.1.7(Alpha), B1.351(Beta), and B.1.617.2(Delta) strains, which appear to have increased transmissibility, were detected. These strains accounting for the high proportion of newly diagnosed cases spread rapidly over the world. Particularly, the Delta variant has been reported to account for a vast majority of the infections in several countries over the last few weeks. The application of biosensors in the detection of SARS-CoV-2 is important for the control of the COVID-19 pandemic. Due to high demand for SARS-CoV-2 genotyping, it is urgent to develop reliable and efficient systems based on integrated multiple biosensor technology for rapid detection of multiple SARS-CoV-2 mutations simultaneously. This is important not only for the detection and analysis of the current but also for future mutations. Novel biosensors combined with other technologies can be used for the reliable and effective detection of SARS-CoV-2 mutants.

Publication types

Review