Polymorphisms of the genes ABCG2, SLC22A12 and XDH and their relation with hyperuricemia and hypercholesterolemia in Mexican young adults

F1000Res. 2021 Mar 17:10:217. doi: 10.12688/f1000research.46399.2. eCollection 2021.

Abstract

Background: Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. Methods: A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of age were genotyped for the ABCG2 (Q191K), SLC22A12 (517G>A), and XDH (518T>C) polymorphisms, as predisposing factors of hyperuricemia. Biochemical parameters were measured by spectrophotometry, while genetic polymorphisms were analyzed by real-time PCR. An analysis of the risk of hyperuricemia in relation to the variables studied was carried out using a logistic regression. Results: Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia ( p ≤ 0.05). The ABCG2 polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17, p = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48, p = 0.003), employing a dominant model, but only in male participants. Conclusions: The ABCG2 (Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males.

Keywords: ABCG2; SLC22A12; XDH; hypercholesterolemia; hyperuricemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2 / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Hypercholesterolemia* / genetics
  • Hyperuricemia* / genetics
  • Male
  • Neoplasm Proteins / genetics
  • Organic Anion Transporters* / genetics
  • Organic Cation Transport Proteins / genetics
  • Polymorphism, Single Nucleotide
  • Uric Acid
  • Young Adult

Substances

  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • Neoplasm Proteins
  • Organic Anion Transporters
  • Organic Cation Transport Proteins
  • SLC22A12 protein, human
  • Uric Acid

Grants and funding

This study was funded by The Facultad de Ciencias Químicas, project assigned to Juan Manuel Vargas Morales, and CIACYT-Medicina, project assigned to Celia Aradillas García, Universidad Autónoma de San Luis Potosí, México.