The value of contrast-enhanced ultrasound for the diagnosis of metastatic cervical lymph nodes of papillary thyroid carcinoma: A systematic review and meta-analysis

J Clin Ultrasound. 2022 Jan;50(1):60-69. doi: 10.1002/jcu.23073. Epub 2021 Oct 8.

Abstract

To investigate the diagnostic efficiency of contrast-enhanced ultrasound (CEUS) for the diagnosis of cervical lymph nodes metastasis (CLNM) of papillary thyroid carcinoma (PTC), eight available datasets of seven qualified articles before March 31, 2021 were included after a comprehensive search. Meta-analysis results showed that CEUS demonstrated acceptable diagnostic performance in the diagnosis of CLNM of PTC. Furthermore, meta-regression analysis was conducted to identify the reasons for heterogeneity and the results indicated that the criteria of CEUS for the diagnosis of CLNM in PTC need to be unified.

Keywords: lymph nodes; lymphatic metastasis; meta-analysis; papillary thyroid neoplasm.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Humans
  • Lymph Nodes / diagnostic imaging
  • Lymphatic Metastasis / diagnostic imaging
  • Retrospective Studies
  • Risk Factors
  • Thyroid Cancer, Papillary / diagnostic imaging
  • Thyroid Neoplasms* / diagnostic imaging
  • Ultrasonography