A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3

Jonathan Bailey; Luiz Pedro Carvalho

doi:10.1016/j.str.2021.09.007

A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3

Structure. 2021 Oct 7;29(10):1091-1093. doi: 10.1016/j.str.2021.09.007.

Authors

Jonathan Bailey¹, Luiz Pedro Carvalho²

Affiliations

¹ Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
² Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: Luiz.Carvalho@crick.ac.uk.

PMID: 34624211
DOI: 10.1016/j.str.2021.09.007

Abstract

In this issue of Structure, Adams et al. (2021) present the cryo-EM structure of Mtb MmpL3 and create a structure-based road map of resistance determinants likely to develop in response to clinical use of MmpL3 inhibitors. This structure-resistance correlation map may aid in the development of next-generation antituberculars to circumvent resistance.

Publication types

Comment

MeSH terms

Antitubercular Agents
Bacterial Proteins / metabolism
Membrane Transport Proteins
Mycobacterium tuberculosis* / metabolism

Substances

Antitubercular Agents
Bacterial Proteins
Membrane Transport Proteins