Proton Pump Inhibitor-Associated Large Hyperplastic Polyp in Non- Helicobacter pylori-Infected Stomach

Kimitoshi Kubo; Noriko Kimura; Norishige Maiya; Soichiro Matsuda; Momoko Tsuda; Takeshi Mizushima; Mototsugu Kato

doi:10.1159/000514530

Proton Pump Inhibitor-Associated Large Hyperplastic Polyp in Non- Helicobacter pylori-Infected Stomach

Case Rep Gastroenterol. 2021 Jun 21;15(2):539-544. doi: 10.1159/000514530. eCollection 2021 May-Aug.

Authors

Kimitoshi Kubo¹, Noriko Kimura², Norishige Maiya¹, Soichiro Matsuda¹, Momoko Tsuda¹, Takeshi Mizushima¹, Mototsugu Kato¹

Affiliations

¹ Departments of Gastroenterology and Pathology, Hakodate, Japan.
² National Hospital Organization Hakodate National Hospital, Hakodate, Japan.

Abstract

A proton pump inhibitor (PPI)-associated hyperplastic polyp (HP) in the non-Helicobacter pylori-infected stomach is rare, and its endoscopic features remain poorly described. A 42-year-old man with tarry stool was referred to our hospital for examination and treatment. He had taken PPI for 14 years and was confirmed to be H. pylori-negative. Transnasal endoscopy revealed bleeding from a 20-mm, reddish pedunculated polyp with a nodular surface, located in the greater curvature of the upper gastric body. Endoscopic mucosal resection was performed, and the lesion was diagnosed as an HP. To our knowledge, this report represents a valuable addition to the HP literature describing a rare case of PPI-associated large HP in the non-H. pylori-infected stomach.

Keywords: Helicobacter pylori−negative status; Hyperplastic polyp; Linked color imaging; Proton pump inhibitor.

Publication types

Case Reports