Exploitation of a novel allosteric binding region in DNA gyrase and its implications for antibacterial drug discovery

Future Med Chem. 2021 Dec;13(24):2125-2127. doi: 10.4155/fmc-2021-0266. Epub 2021 Oct 4.

Authors

Kyle M Orritt¹, Anthony Maxwell², Colin Wg Fishwick¹, Martin J McPhillie¹

Affiliations

¹ School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
² Department of Biochemistry & Metabolism, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

PMID: 34605249
DOI: 10.4155/fmc-2021-0266

No abstract available

Keywords: DNA gyrase; allosteric inhibitors; antimicrobial resistance; topoisomerase IV.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
DNA Gyrase / metabolism*
Drug Discovery*
Humans
Topoisomerase Inhibitors / chemical synthesis
Topoisomerase Inhibitors / chemistry
Topoisomerase Inhibitors / pharmacology*

Substances

Anti-Bacterial Agents
Topoisomerase Inhibitors
DNA Gyrase

Grants and funding