Early-Onset Parkinson's Disease: A Novel Deletion Comprising the DJ-1 and TNFRSF9 Genes

Mov Disord. 2021 Dec;36(12):2973-2976. doi: 10.1002/mds.28812. Epub 2021 Oct 3.

Abstract

Patients with mutations in DJ-1 have early-onset Parkinson's disease and slow progression. Here we describe a Turkish family with a large deletion in the neighboring genes DJ-1 (del exons 1-5) and TNFRSF9 (del exons 1-6), raising the question if TNFRSF9 is a possible disease modifier.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Exons
  • Humans
  • Parkinson Disease* / genetics
  • Protein Deglycase DJ-1* / genetics
  • Sequence Deletion*
  • Tumor Necrosis Factor Receptor Superfamily, Member 9* / genetics

Substances

  • TNFRSF9 protein, human
  • Tumor Necrosis Factor Receptor Superfamily, Member 9
  • PARK7 protein, human
  • Protein Deglycase DJ-1