Abstract
Patients with mutations in DJ-1 have early-onset Parkinson's disease and slow progression. Here we describe a Turkish family with a large deletion in the neighboring genes DJ-1 (del exons 1-5) and TNFRSF9 (del exons 1-6), raising the question if TNFRSF9 is a possible disease modifier.
© 2021 International Parkinson and Movement Disorder Society.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Age of Onset
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Exons
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Humans
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Parkinson Disease* / genetics
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Protein Deglycase DJ-1* / genetics
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Sequence Deletion*
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Tumor Necrosis Factor Receptor Superfamily, Member 9* / genetics
Substances
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TNFRSF9 protein, human
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Tumor Necrosis Factor Receptor Superfamily, Member 9
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PARK7 protein, human
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Protein Deglycase DJ-1