Promising New Salt of Oseltamivir

A I Kalashnikov; E G Sonina; D A Kulagina; S V Sysolyatin; E A Prokop'eva; E Yu Sherstoboev

doi:10.1007/s11094-021-02456-3

Promising New Salt of Oseltamivir

Pharm Chem J. 2021;55(6):540-543. doi: 10.1007/s11094-021-02456-3. Epub 2021 Sep 25.

Authors

A I Kalashnikov¹, E G Sonina¹, D A Kulagina¹, S V Sysolyatin¹, E A Prokop'eva², E Yu Sherstoboev³

Affiliations

¹ Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences, 1 Sotsialisticheskaya St., Biysk, Altai Krai 659322 Russia.
² Federal Research Center of Fundamental and Translational Medicine, 2 Timakova St., Novosibirsk, 630117 Russia.
³ E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, 3 Prosp. Lenina, Tomsk, 634028 Russia.

Abstract

A synthetic method for the promising new drug oseltamivir ethoxysuccinate is described in detail. Various conditions for obtaining the target substance are considered. Its complete physicochemical characteristics are given. The obtained agent is shown to be effective against influenza virus A (H1N1)pdm09.

Keywords: antiviral activity; oseltamivir salts.