Listeria monocytogenes Ankle Osteomyelitis in a Patient with Rheumatoid Arthritis on Adalimumab: A Report and Literature Review of Listeria monocytogenes Osteomyelitis

Intern Med. 2021;60(19):3171-3176. doi: 10.2169/internalmedicine.5633-20. Epub 2021 Oct 1.

Abstract

Localized Listeria infection predominantly occurs in the prosthetic and hip joints. We herein report a case of Listeria monocytogenes ankle osteomyelitis in a 73-year-old man receiving adalimumab who was transferred to our hospital because of suspected rheumatoid arthritis (RA) flare. He reported a four-month history of left ankle swelling. A surgical biopsy revealed L. monocytogenes osteomyelitis in the left tibia and talus bones. The patient was successfully treated with antibiotics and surgical debridement. Thus, infection due to L. monocytogenes can present as ankle osteomyelitis in immunocompromised patients and may mimic an RA flare.

Keywords: Listeria monocytogenes, osteomyelitis; adalimumab; rheumatoid arthritis; tumor necrosis factor (TNF)-alpha inhibitor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adalimumab / adverse effects
  • Aged
  • Ankle
  • Arthritis, Rheumatoid* / complications
  • Arthritis, Rheumatoid* / drug therapy
  • Humans
  • Listeria monocytogenes*
  • Listeriosis* / complications
  • Listeriosis* / diagnosis
  • Listeriosis* / drug therapy
  • Male
  • Osteomyelitis* / diagnosis
  • Osteomyelitis* / drug therapy

Substances

  • Adalimumab