"The possible implication of endothelin in the pathology of COVID-19-induced pulmonary hypertension"

Omnia Azmy Nabeh; Lamiaa Mohammed Matter; Mahmoud Ahmed Khattab; Esraa Menshawey

doi:10.1016/j.pupt.2021.102082

"The possible implication of endothelin in the pathology of COVID-19-induced pulmonary hypertension"

Pulm Pharmacol Ther. 2021 Dec:71:102082. doi: 10.1016/j.pupt.2021.102082. Epub 2021 Oct 1.

Authors

Omnia Azmy Nabeh¹, Lamiaa Mohammed Matter², Mahmoud Ahmed Khattab³, Esraa Menshawey⁴

Affiliations

¹ M.Sc/ Assistant Lecturer, Department of Medical Pharmacology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt; M.Sc, Cardiovascular Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: omnia.azmy@kasralainy.edu.eg.
² MD/Lecturer, Department of Medical Pharmacology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt; Professional Diploma of Family Medicine, Arab Institute for Continuing Professional Development, Arab Medical Union, Egypt. Electronic address: lamiaa.mattar@yahoo.com.
³ M.Sc/ Assistant Lecturer, Department of Medical Pharmacology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt; M.Sc Internal Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: dr_mahmoudkhattab@yahoo.com.
⁴ Medical Student, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: esraa.menshawey@gmail.com.

Abstract

COVID-19 pandemic has changed the world dramatically since was first reported in Wuhan city, China [1]. Not only as a respiratory illness that could lead to fatal respiratory failure, but also some evidences suggest that it can propagate as a chronic disease associated with a variety of persistent post COVID-19 pathologies that affect patients' life [2,3]. Pulmonary hypertension (PH) is one of the challenging diseases that may develop as a consequence of SARS-COV-2 infection in some COVID-19 survivors [4,5]. The vasopressor, proliferative, proinflammatory, and prothrombotic actions of endothelin [6] may be encountered in the COVID-19-induced PH pathology. And so, endothelin blockers may have an important role to restrict the development of serious PH outcomes with special precautions considering patients with significant hypoxemia.

Keywords: Endothelin; Fibrosis; Inflammation; Post COVID syndrome; Pulmonary hypertension; Thrombosis.

Publication types

Review

MeSH terms

COVID-19* / complications
Endothelins*
Humans
Hypertension, Pulmonary* / virology
Pandemics

Substances

Endothelins