FGF/FGFR signaling: From lung development to respiratory diseases

Lehe Yang; Feng Zhou; Dandan Zheng; Dandan Wang; Xiaokun Li; Chengguang Zhao; Xiaoying Huang

doi:10.1016/j.cytogfr.2021.09.002

FGF/FGFR signaling: From lung development to respiratory diseases

Cytokine Growth Factor Rev. 2021 Dec:62:94-104. doi: 10.1016/j.cytogfr.2021.09.002. Epub 2021 Sep 20.

Authors

Lehe Yang¹, Feng Zhou¹, Dandan Zheng¹, Dandan Wang², Xiaokun Li³, Chengguang Zhao⁴, Xiaoying Huang⁵

Affiliations

¹ Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, China.
² Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, China; School of Pharmaceutical Sciences, Wenzhou Medical University, University Town, Wenzhou, Zhejiang 325035, China.
³ School of Pharmaceutical Sciences, Wenzhou Medical University, University Town, Wenzhou, Zhejiang 325035, China. Electronic address: xiaokunli@wmu.edu.cn.
⁴ Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, China; School of Pharmaceutical Sciences, Wenzhou Medical University, University Town, Wenzhou, Zhejiang 325035, China. Electronic address: zhaochengguang@wmu.edu.cn.
⁵ Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, China. Electronic address: huangxiaoying@wzhospital.cn.

PMID: 34593304
DOI: 10.1016/j.cytogfr.2021.09.002

Abstract

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system regulates a variety of biological processes, including embryogenesis, angiogenesis, wound repair, tissue homeostasis, and cancer. It exerts these regulatory functions by controlling proliferation, differentiation, migration, survival, and metabolism of target cells. The morphological structure of the lung is a complex tree-like network for effective oxygen exchange, and the airway terminates in the middle and distal ends of many alveoli. FGF/FGFR signaling plays an important role in the pathophysiology of lung development and pathogenesis of various human respiratory diseases. Here, we mainly review recent advances in FGF/FGFR signaling during human lung development and respiratory diseases, including lung cancer, acute lung injury (ALI), pulmonary arterial hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis.

Keywords: FGF; FGFR; Lung cancer; Lung development; Respiratory diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fibroblast Growth Factors
Humans
Lung
Neovascularization, Pathologic
Pulmonary Disease, Chronic Obstructive*
Receptors, Fibroblast Growth Factor*
Signal Transduction

Substances

Receptors, Fibroblast Growth Factor
Fibroblast Growth Factors