Abstract
We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.
MeSH terms
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Catalysis
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Hydrogen-Ion Concentration
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Hydrolysis
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Peptide Nucleic Acids / chemistry*
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Phenazines / chemistry*
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Pyridines / chemistry*
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RNA / chemistry*
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Ribonucleases / chemistry
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Zinc / chemistry
Substances
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Peptide Nucleic Acids
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Phenazines
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Pyridines
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RNA
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Ribonucleases
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Zinc