Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity

Chem Commun (Camb). 2021 Oct 19;57(83):10911-10914. doi: 10.1039/d1cc04383h.

Abstract

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

MeSH terms

  • Catalysis
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Peptide Nucleic Acids / chemistry*
  • Phenazines / chemistry*
  • Pyridines / chemistry*
  • RNA / chemistry*
  • Ribonucleases / chemistry
  • Zinc / chemistry

Substances

  • Peptide Nucleic Acids
  • Phenazines
  • Pyridines
  • RNA
  • Ribonucleases
  • Zinc