PROTAC cell permeability and oral bioavailability: a journey into uncharted territory

Future Med Chem. 2022 Jan;14(3):123-126. doi: 10.4155/fmc-2021-0208. Epub 2021 Sep 29.
No abstract available

Keywords: ADME/Tox; drug design; in vitro assays; molecular chameleon; oral druggable space.

Publication types

  • Editorial

MeSH terms

  • Administration, Oral
  • Biological Availability
  • Cell Membrane / drug effects
  • Enzyme Inhibitors / administration & dosage
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacokinetics*
  • Humans
  • Ligands
  • Molecular Structure
  • Permeability / drug effects
  • Proteolysis / drug effects
  • Ubiquitin-Protein Ligases / antagonists & inhibitors*
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Enzyme Inhibitors
  • Ligands
  • Ubiquitin-Protein Ligases