Therapy of paraneoplastic pemphigus with Rituximab: A case report

Dermatol Ther. 2021 Nov;34(6):e15144. doi: 10.1111/dth.15144. Epub 2021 Oct 6.

Abstract

We report a case of 39-year-old female patient with paraneoplastic pemphigus (PNP) associated with thymoma treated with rituximab plus corticosteroids and methotrexate. After rituximab therapy for 8 weeks, oral ulcerations had cured, lesions on the trunk and limbs improved. Rituximab may be useful for PNP therapy, but further studies are necessary to confirm this hypothesis.

Keywords: Rituximab; paraneoplastic pemphigus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Paraneoplastic Syndromes* / diagnosis
  • Paraneoplastic Syndromes* / drug therapy
  • Paraneoplastic Syndromes* / etiology
  • Pemphigus* / diagnosis
  • Pemphigus* / drug therapy
  • Pemphigus* / etiology
  • Rituximab / therapeutic use
  • Thymoma*
  • Thymus Neoplasms*

Substances

  • Rituximab