Human settlement environment is space places closely related to human production and life, and also surface spaces inseparable from human activities. As a coastal city in the east of China, Qingdao has a relatively high level of urbanization. However, it also along with many urban problems at the same time, among which the problem of human settlement environment has attracted more and more general attention from people. According to the characteristics of human settlement environment in Qingdao, the research constructs an index system with 10 index factors from natural factors and humanity factors, and proposes a comprehensive evaluation model. Evaluate and grade suitability of human settlement environment in Qingdao, explore the spatial aggregation and differentiation of the quality of human settlement environment, and reveal the internal connection of spatial evolution. The results indicate that the overall livability of Qingdao is relatively good, showing a multi-center and radial driving development. The distribution of livability is uneven, showing a decreasing spatial distribution law from the coast to the inland, and the quality of human settlement environment in Jiaozhou Bay and the coastal areas is relatively high. Qingdao is mainly based on natural livability, supplemented by humanity livability, compared with natural suitability, the spatio-temporal evolution characteristics of humanity livability have experienced three stages: rising-contradictory rising-harmonious rising. The quality of human settlement environment has obvious spatial correlation and is positively correlated with the degree of agglomeration, and the agglomeration of blocks with a higher quality of human settlement environment is higher than that of blocks with a lower level. The rule of human settlement environment changing over time is that areas with high quality of human settlement environment begin to shift from the city center to the north and the south, transforming into multi-point development, and overall environmental suitability has been improved. According to the results of the comprehensive evaluation, combined with its local development status and policies, the research puts forward developmental suggestions for the construction of human settlement environment in Qingdao, and provides decision-making basis for relevant departments to solve the problem of deterioration of human settlement environment.