The G protein database, GproteinDb

Nucleic Acids Res. 2022 Jan 7;50(D1):D518-D525. doi: 10.1093/nar/gkab852.

Abstract

Two-thirds of signaling substances, several sensory stimuli and over one-third of drugs act via receptors coupling to G proteins. Here, we present an online platform for G protein research with reference data and tools for analysis, visualization and design of scientific studies across disciplines and areas. This platform may help translate new pharmacological, structural and genomic data into insights on G protein signaling vital for human physiology and medicine. The G protein database is accessible at https://gproteindb.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Databases, Protein*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / drug effects
  • Eukaryotic Cells / metabolism
  • GTP-Binding Proteins / antagonists & inhibitors
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Models, Molecular
  • Molecular Sequence Annotation
  • Mutation
  • Prescription Drugs / chemistry*
  • Prescription Drugs / pharmacology
  • Protein Binding
  • Protein Conformation, alpha-Helical
  • Protein Conformation, beta-Strand
  • Protein Interaction Domains and Motifs
  • Receptors, G-Protein-Coupled / antagonists & inhibitors
  • Receptors, G-Protein-Coupled / chemistry
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / pharmacology
  • Software*
  • Structure-Activity Relationship

Substances

  • Prescription Drugs
  • Receptors, G-Protein-Coupled
  • Small Molecule Libraries
  • GTP-Binding Proteins