Dermatologic toxicities of targeted antineoplastic agents and immune checkpoint inhibitor therapy in pediatric patients: A systematic review

Lucy Y Liu; Joyce M C Teng; Sheri L Spunt; Jenna L Strelo; Bernice Y Kwong; Lisa C Zaba

doi:10.1002/pbc.29346

Dermatologic toxicities of targeted antineoplastic agents and immune checkpoint inhibitor therapy in pediatric patients: A systematic review

Pediatr Blood Cancer. 2021 Dec;68(12):e29346. doi: 10.1002/pbc.29346. Epub 2021 Sep 26.

Authors

Lucy Y Liu¹, Joyce M C Teng^{1

2}, Sheri L Spunt³, Jenna L Strelo⁴, Bernice Y Kwong^{1

4}, Lisa C Zaba^{1

4}

Affiliations

¹ Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA.
² Department of Dermatology, Division of Pediatric Dermatology, Stanford University School of Medicine, Stanford, California, USA.
³ Department of Pediatrics, Division of Hematology/Oncology, Stanford University School of Medicine, Stanford, California, USA.
⁴ Cutaneous Oncology, Stanford University Medical Center and Cancer Institute, Stanford, California, USA.

PMID: 34569142
DOI: 10.1002/pbc.29346

Abstract

Cutaneous adverse events (cAEs) from targeted antineoplastic agents and immune checkpoint inhibitors are common in children with cancer and may lead to dose reduction or cessation of critical oncologic treatment. Timely diagnosis and proper management of cAEs in pediatric oncology patients is essential to optimize ongoing cancer-directed therapy and improve quality of life. This systematic review of published studies summarizes dermatologic toxicities to targeted anticancer treatments and immune checkpoint inhibitors.

Keywords: cancer; cutaneous; immunotherapy; oncodermatology; pediatric; targeted therapy.

Publication types

Review
Systematic Review

MeSH terms

Antineoplastic Agents* / adverse effects
Child
Humans
Immune Checkpoint Inhibitors
Immunotherapy / adverse effects
Neoplasms* / drug therapy
Neoplasms* / etiology
Quality of Life
Skin

Substances

Antineoplastic Agents
Immune Checkpoint Inhibitors