Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification

Chao Zhang; Dongdong Zheng; Weijing Feng; Huanji Zhang; Feng Han; Wanbing He; Aiting Liu; Hui Huang; Jie Chen

doi:10.3389/fcvm.2021.710090

Olanzapine: Association Between a Typical Antipsychotic Drug and Aortic Calcification

Front Cardiovasc Med. 2021 Sep 10:8:710090. doi: 10.3389/fcvm.2021.710090. eCollection 2021.

Authors

Chao Zhang¹, Dongdong Zheng², Weijing Feng¹, Huanji Zhang³, Feng Han⁴, Wanbing He¹, Aiting Liu³, Hui Huang³, Jie Chen⁵

Affiliations

¹ Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
² Department of Psychiatry, Psychiatric Hospital of Guangzhou Civil Affairs Bureau, Guangzhou, China.
³ Cardiovascular Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
⁴ Department of Ultrasound, Cancer Center, Sun Yat-sen University, Guangzhou, China.
⁵ Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Abstract

Aims: This study concentrates on the relationship between antipsychotic drugs (APDs) and aortic calcification. Methods: All 56 patients with schizophrenia were divided into two groups according to aortic calcification index. APD equivalent dose was calculated via defined daily doses method. Results: In schizophrenia patients with higher aortic calcification index scores, APD equivalent doses were lower. APD equivalent dose was negatively related to aortic calcification index. Although equivalent APD dose in patients without olanzapine treatment was negatively related to aortic calcification index, it seems that equivalent APD dose did not associate with aortic calcification. Conclusion: Aortic calcification is negatively associated with APD dose in schizophrenia patients. Olanzapine seems to be vital to the relationship between aortic calcification and APD treatment.

Keywords: antipsychotic drugs; aortic calcification; mental illness; olanzapine; schizophrenia.