Intraoperative Remifentanil Dosage in Surgery for Adolescent Idiopathic Scoliosis Does Not Increase Postoperative Opioid Consumption When Combined With Epidural Analgesia: A Retrospective Cohort Study

Yoshitaka Aoki; Hiroki Iwata; Chieko Akinaga; Yuki Shiko; Yohei Kawasaki; Kensuke Kobayashi; Hiroki Nozawa; Hiroyuki Kinoshita; Yoshiki Nakajima

doi:10.7759/cureus.17361

Intraoperative Remifentanil Dosage in Surgery for Adolescent Idiopathic Scoliosis Does Not Increase Postoperative Opioid Consumption When Combined With Epidural Analgesia: A Retrospective Cohort Study

Cureus. 2021 Aug 22;13(8):e17361. doi: 10.7759/cureus.17361. eCollection 2021 Aug.

Authors

Yoshitaka Aoki¹, Hiroki Iwata¹, Chieko Akinaga¹, Yuki Shiko², Yohei Kawasaki², Kensuke Kobayashi¹, Hiroki Nozawa¹, Hiroyuki Kinoshita³, Yoshiki Nakajima¹

Affiliations

¹ Department of Anesthesiology and Intensive Care Medicine, Hamamatsu University School of Medicine, Hamamatsu, JPN.
² Clinical Research Center, Chiba University Hospital, Chiba, JPN.
³ Department of Anesthesiology, Seirei Mikatahara General Hospital, Hamamatsu, JPN.

Abstract

Background In adults, high-dose remifentanil during surgery has been reported to increase postoperative opioid consumption, but this has not been well documented in children. Multimodal analgesia is recommended in the perioperative period for adolescent idiopathic scoliosis (AIS), but no report has examined opioid consumption under epidural analgesia, which is one of the most common types of analgesia. Aims To investigate the association between intraoperative remifentanil dosage and postoperative opioid consumption in AIS in the setting of combined epidural analgesia for postoperative multimodal analgesia. Methods In this retrospective cohort study, patients aged 10-18 years who underwent surgery for scoliosis and epidural analgesia for postoperative pain between July 2012 and April 2019 were included. The primary endpoint was the association between intraoperative cumulative weight-adjusted remifentanil dosage and logarithmic transformation of cumulative weight-adjusted fentanyl consumption in the intensive care unit (ICU). Nonopioid analgesics were investigated as secondary endpoints. An epidural catheter was inserted by the surgeon intraoperatively, and a local anesthetic was administered at the end of the surgery. Multivariate linear regression analysis with adjustment for confounders was performed for all analyses. Results In total, 142 patients were included, and the median intraoperative remifentanil dosage for all patients was 0.27 (interquartile range, 0.24-0.34) µg/kg/min. No association was observed between cumulative weight-adjusted intraoperative dosage of remifentanil and fentanyl, even after adjusting for potential confounders (slope = -1.25; 95% confidence interval [CI], -4.35 to 1.85; P = 0.43). No association was observed between nonopioid analgesic use and intraoperative remifentanil dosage. Conclusion No association was noted between remifentanil dosage during surgery for AIS and postoperative opioid consumption with epidural analgesia. However, this study has limitations due to its retrospective design; thus, further prospective studies are warranted.

Keywords: epidural analgesia; hyperalgesia; opioid; remifentanil; scoliosis.