Association of parvovirus B19 and myocarditis/dilated cardiomyopathy: A systematic review and meta-analysis

Alireza Khatami; Mohammad Hossein Razizadeh; Monire Ghadirali; Shahrooz Yazdani; Saeed Bahadory; Alireza Soleimani

doi:10.1016/j.micpath.2021.105207

Association of parvovirus B19 and myocarditis/dilated cardiomyopathy: A systematic review and meta-analysis

Microb Pathog. 2022 Jan:162:105207. doi: 10.1016/j.micpath.2021.105207. Epub 2021 Sep 24.

Authors

Alireza Khatami¹, Mohammad Hossein Razizadeh², Monire Ghadirali³, Shahrooz Yazdani⁴, Saeed Bahadory⁵, Alireza Soleimani⁶

Affiliations

¹ Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: AKH.Alirezakhatami@gmail.com.
² Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
³ Department of Virology, School of Public Health, Tehran University of Medical Sciences, Iran.
⁴ Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Iran.
⁵ Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
⁶ Department of Infectious Diseases, School of Medicine, Alborz University of Medical Sciences, Iran.

PMID: 34563612
DOI: 10.1016/j.micpath.2021.105207

Abstract

Background: The potential association between Parvovirus B19 and heart disease has been controversial. The aim of the present study was to report the prevalence of B19 in myocarditis and dilated cardiomyopathy (DCM) as well as measure the statistical association between them.

Methods: Our systematic search was carried out to retrieve published articles between January 2000 and March 2021 using three major databases: PubMed, Scopus, and Web of Science, as well as the Google Scholar search engine. The overall prevalence of HAV, pooled odds ratio, and heterogeneity were estimated by comprehensive meta-analysis (V2.2, Biostat) software.

Results: The overall prevalence results in myocarditis and DCM were 23.7% (95% CI: 18.7%-29.5%) and 34.1% (95% CI: 23.8%-46.1%) respectively; in addition, the overall OR for B19 and myocarditis was 4.317 (95% CI, 1.831-10.180) versus 1.163 (95% CI: 0.706-1.916) for B19 and DCM.

Conclusion: Our findings have shown a significant association between Parvovirus B19 and myocarditis with a high prevalence. In the case of DCM, no significant association was found while the prevalence of the virus was relatively high.

Keywords: DCM; Dilated cardiomyopathy; Heart failure; Meta-analysis; Myocarditis; Parvovirus B19.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Cardiomyopathy, Dilated* / epidemiology
Humans
Myocarditis* / epidemiology
Parvoviridae Infections* / epidemiology
Parvovirus B19, Human*
Prevalence