Advances in analytical techniques and quality control of traditional Chinese medicine injections

Yujia Tu; Linnan Li; Zhengtao Wang; Li Yang

doi:10.1016/j.jpba.2021.114353

Advances in analytical techniques and quality control of traditional Chinese medicine injections

J Pharm Biomed Anal. 2021 Nov 30:206:114353. doi: 10.1016/j.jpba.2021.114353. Epub 2021 Sep 1.

Authors

Yujia Tu¹, Linnan Li¹, Zhengtao Wang², Li Yang³

Affiliations

¹ The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
² The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
³ The MOE Key Laboratory of Standardization of Chinese Medicines and the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China. Electronic address: yl7@shutcm.edu.cn.

PMID: 34562802
DOI: 10.1016/j.jpba.2021.114353

Abstract

Traditional Chinese medicine injections (TCMIs) are a new pharmaceutical form in the modernization of traditional Chinese medicines (TCMs). Its efficacy is rapid, the curative effect is improved, and is widely used in critical and acute diseases, complicated and severe diseases, and other treatment. However, with the broad applications of TCMIs, clinical adverse reactions frequently occur, and safety problems become more prominent. Therefore, the quality control of TCMIs is essential. Chemical analysis methods and biological analysis methods are widely used in the quality control of TCMIs. This article describes the current status of TCMIs, the analytical techniques, and methods currently used, and the quality control of TCMIs. A summary of the advantages and disadvantages of the current analysis methods is presented. An overview of the quality control of TCMIs is introduced. In addition, emerging techniques of the quality control of TCMIs are introduced.

Keywords: Adverse drug reactions; Analytical techniques; High-performance liquid chromatography-mass spectrometry; Quality control; Traditional Chinese medicine; Traditional Chinese medicine injection.

Publication types

Review

MeSH terms

Drugs, Chinese Herbal*
Injections
Medicine, Chinese Traditional*
Quality Control

Substances

Drugs, Chinese Herbal