Aspirin and growth, rupture of unruptured intracranial aneurysms: A systematic review and meta-analysis

Abstract

Objectives: Aspirin has been suggested as a potential therapeutic strategy to prevent the growth and rupture of unruptured intracranial aneurysms (UIAs), but there is still controversy. The aim of this systematic review and meta-analysis is to determine the association between aspirin use and growth, rupture of UIAs.

Methods: We performed a systematic literature search of electronic databases to identify cohort and case-control studies investigating the relationship between aspirin use and growth or rupture of UIAs. Pooled odds ratio (OR) with corresponding 95% confidence interval (CI) were calculated using a random effects model. Heterogeneity among studies was quantified using the I² statistic, and potential publication bias was assessed using funnel plots. Sensitivity analysis was performed to verify the robustness of the intention-to-treat results. Subgroup analysis was conducted according to the frequency of aspirin use.

Results: We identified 8 studies comprising 10,518 participants. The risk of bias was low to moderate. The pooled estimate showed that aspirin use was associated with a lower likelihood of growth of UIAs (OR = 0.25, 95% CI = 0.11-0.55; p = 0.0005) without statistical heterogeneity (p for Cochran Q statistic = 0.62, I² = 0%). Likewise, aspirin intake also significant decreased 58% risk of intracranial aneurysms rupture (OR = 0.42, 95% CI = 0.29-0.60; p < 0.00001) with moderate heterogeneity (p for Cochran Q statistic = 0.005, I² = 66%). Similar results were observed in the sensitivity analysis. Pooled OR of aspirin frequency subgroup analysis for less than or equal to 2 times per week was 0.82 (95%CI = 0.40-1.72; I² = 0%), for at least 3 times per week to daily was 0.25 (95%CI = 0.12-053; I² = 0%), for daily was 0.59 (95%CI: 0.47-0.74; I² = 0%), and for unknown was 0.26 (95%CI: 0.15-0.45; I² = 51%).

Conclusions: The results of this systematic review and meta-analysis indicates a beneficial effect of aspirin on growth and rupture of UIAs.

Keywords: Aspirin; Growth; Meta-analysis; Rupture; Unruptured intracranial aneurysms.