Update on Modulators of Quorum Sensing Pathways in Pseudomonas aeruginosa

Curr Top Med Chem. 2021;21(23):2101-2108. doi: 10.2174/1568026621666210924160004.

Abstract

Modulators of quorum sensing pathways in Pseudomonas aeruginosa (PA) gain attention due to their potential therapeutic applications. These chemical agents are viewed as anti-virulence agents capable of increasing the existing therapeutic agents' efficacy against resistant clinical strains. Additionally, they can be utilized in developing anticancer therapeutics, whole-cell biosensors, and artificial biological systems. In this mini-review, we summarize recent (2015-2021) publications on PA's QS modulation.

Keywords: Pseudomonas aeruginosa; quorum sensing; quorum sensing inhibitors.; virulence factors.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents
  • Biosensing Techniques
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / pathogenicity
  • Pseudomonas aeruginosa / physiology*
  • Quorum Sensing / drug effects*
  • Virulence / drug effects

Substances

  • Antineoplastic Agents