Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially

Lingxia Xie; Guomin Wang; Yuzheng Wu; Qing Liao; Shi Mo; Xiaoxue Ren; Liping Tong; Wei Zhang; Min Guan; Haobo Pan; Paul K Chu; Huaiyu Wang

doi:10.1016/j.xinn.2021.100148

Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially

Innovation (Camb). 2021 Aug 5;2(3):100148. doi: 10.1016/j.xinn.2021.100148. eCollection 2021 Aug 28.

Authors

Lingxia Xie¹, Guomin Wang², Yuzheng Wu^{1

2}, Qing Liao¹, Shi Mo², Xiaoxue Ren¹, Liping Tong¹, Wei Zhang³, Min Guan¹, Haobo Pan¹, Paul K Chu², Huaiyu Wang¹

Affiliations

¹ Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
² Department of Physics, Department of Materials Science and Engineering, and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
³ Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Abstract

The immune responses are involved in every stage after implantation but the reported immune-regulated materials only work at the beginning without fully considering the different phases of bone healing. Here, poly(aryl-ether-ether-ketone) (PEEK) is coated with a programmed surface, which rapidly releases interleukin-10 (IL-10) in the first week and slowly delivers dexamethasone (DEX) up to 4 weeks. Owing to the synergistic effects of IL-10 and DEX, an aptly weak inflammation is triggered within the first week, followed by significant M2 polarization of macrophages and upregulation of the autophagy-related factors. The suitable immunomodulatory activities pave the way for osteogenesis and the steady release of DEX facilitates bone regeneration thereafter. The sequential immune-mediated process is also validated by an 8-week implementation on a rat model. This is the first attempt to construct implants by taking advantage of both immune-mediated modulation and sequential regulation spanning all bone regeneration phases, which provides insights into the fabrication of advanced biomaterials for tissue engineering and immunological therapeutics.

Keywords: bone regeneration; immune-mediated osteogenesis; poly(aryl-ether-ether-ketone); sequential release; surface modifications.