The study on the antioxidant and hypolipidemic effect of pollen extracts (Cernitins) was conducted in male mongrel rabbits and Wistar rats. The animals were fed a high-fat diet (HFD) composed of cholesterol, coconut oil and cholic acid, and received pollen extracts (Cernitins) orally (the rabbits over a period of 12 weeks and the rats over a period of 2 weeks). The levels of malondialdehyde (MDA) as an indication of the degree of peroxidation and lipids (cholesterol, triglyceride, separation of lipoproteins into fractions) were measured. The study demonstrated the reduction of MDA concentrations under the influence of Cernitins, suggesting their antioxidant properties. Total cholesterol and triglyceride content was also decreased.