A heavy-ion production channel of 149Tb via 63Cu bombardment of 89Y

John T Wilkinson; Kendall E Barrett; Samuel J Ferran; Sean R McGuinness; Lauren A McIntosh; Mallory McCarthy; Sherry J Yennello; Jonathan W Engle; Suzanne E Lapi; Graham F Peaslee

doi:10.1016/j.apradiso.2021.109935

A heavy-ion production channel of ¹⁴⁹Tb via ⁶³Cu bombardment of ⁸⁹Y

Appl Radiat Isot. 2021 Dec:178:109935. doi: 10.1016/j.apradiso.2021.109935. Epub 2021 Sep 14.

Affiliations

¹ Department of Physics, University of Notre Dame, Notre Dame, IN, 46556, USA. Electronic address: jwilkin5@nd.edu.
² Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, 53715, USA.
³ Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
⁴ Department of Physics, University of Notre Dame, Notre Dame, IN, 46556, USA.
⁵ Cyclotron Institute, Texas A&M University, College Station, TX, 77840, USA.

PMID: 34555596
DOI: 10.1016/j.apradiso.2021.109935

Abstract

The radionuclide ¹⁴⁹Tb (t_1/2 = 4.1 h) is a potential theranostic isotope which can simultaneously be used for targeted-alpha-particle therapy and positron-emission tomography. Feasibility experiments were performed to test a near-symmetric heavy-ion reaction of ⁶³Cu bombardment on monoisotopic ⁸⁹Y. The indirect reaction was studied to avoid isomer production. Offline gamma spectroscopy was used to quantify thick-target physical yields and experimental results show modest agreement to the fusion-evaporation code PACE4. A near-symmetric fission yield was also observed.

Keywords: (149)Tb; Heavy-ions; Isotope production; Theranostics.

MeSH terms

Copper / chemistry*
Half-Life
Radioisotopes / chemistry*
Spectrometry, Gamma
Terbium / chemistry*
Yttrium Isotopes / chemistry*

Substances

Radioisotopes
Terbium-149
Yttrium Isotopes
Terbium
Copper