Maintenance Therapy With the Lowest Effective Dose of Oral Viscous Budesonide in Children With Eosinophilic Esophagitis

Salvatore Oliva; Danila Volpe; Giusy Russo; Silvio Veraldi; Paola Papoff; Carla Giordano; Cosimo Ruggiero; Chiara Maria Trovato; Gianluca Terrin; Danilo Rossetti

doi:10.1016/j.cgh.2021.09.020

Maintenance Therapy With the Lowest Effective Dose of Oral Viscous Budesonide in Children With Eosinophilic Esophagitis

Clin Gastroenterol Hepatol. 2022 Dec;20(12):2905-2907.e2. doi: 10.1016/j.cgh.2021.09.020. Epub 2021 Sep 20.

Affiliations

¹ Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza-University of Rome, Rome, Italy. Electronic address: salvatore.oliva@uniroma1.it.
² Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza-University of Rome, Rome, Italy.
³ Pediatric Intensive Care Unit, Maternal and Child Health Department, Sapienza-University of Rome, Rome, Italy.
⁴ Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy.

PMID: 34555518
DOI: 10.1016/j.cgh.2021.09.020

Abstract

Eosinophilic esophagitis (EoE) is an immune-mediated condition characterized by symptoms of esophageal dysfunction and an eosinophilic inflammation of the esophagus.¹ Swallowed topical steroids represent one of the possible strategies for inducing and maintaining remission in EoE.² To date, a validated maintenance strategy has yet to be defined, especially in children. The available evidence suggests decreasing the dose after a successful induction therapy.³ No study has reported the efficacy of a continuous progressive dose reduction; thus, it is unknown if all patients need to use the same dosages and for how long.^4,5.

MeSH terms

Budesonide
Child
Eosinophilic Esophagitis* / diagnosis
Glucocorticoids / therapeutic use
Humans
Steroids / therapeutic use

Substances

Budesonide
Glucocorticoids
Steroids