A rare case of atypical chronic myeloid leukemia associated with t(8;22)(p11.2;q11.2)/ BCR-FGFR1 rearrangement: A case report and literature review

Cancer Genet. 2021 Nov:258-259:69-73. doi: 10.1016/j.cancergen.2021.09.001. Epub 2021 Sep 13.

Abstract

Myeloid/lymphoid neoplasm with t(8;22)(p11.2;q11.2)/BCR-FGFR1 is an extremely rare diagnosis, with few reported cases to date. In contrast to other FGFR1-partner rearrangements that are associated with chronic eosinophilic leukemia, acute myeloid leukemia, and/or lymphoblastic lymphoma, patients with BCR-FGFR1 have a myeloproliferative disorder that closely resembles chronic myeloid leukemia (CML). The current report describes a rare case of a 61 year old man with an atypical CML phenotype associated with t(8;22)(p11.2;q11.2)/BCR-FGFR1. A literature review is presented to enhance the awareness of this rare diagnostic entity.

Keywords: 8p11 myeloproliferative syndrome; Chronic myeloid leukemia; Fibroblast growth factor receptor 1.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Chromosomes, Human, Pair 22 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • Gene Rearrangement*
  • Humans
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / genetics
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology*
  • Male
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins c-bcr / genetics*
  • Receptor, Fibroblast Growth Factor, Type 1 / genetics*
  • Translocation, Genetic*

Substances

  • FGFR1 protein, human
  • Receptor, Fibroblast Growth Factor, Type 1
  • BCR protein, human
  • Proto-Oncogene Proteins c-bcr