Cliniatines A-C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase

Yusuke Hirasawa; Tomoko Tanaka; Shiro Hirasawa; Chin Piow Wong; Nahoko Uchiyama; Toshio Kaneda; Yukihiro Goda; Hiroshi Morita

doi:10.1007/s11418-021-01570-6

Cliniatines A-C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase

J Nat Med. 2022 Jan;76(1):171-177. doi: 10.1007/s11418-021-01570-6. Epub 2021 Sep 22.

Authors

Yusuke Hirasawa¹, Tomoko Tanaka², Shiro Hirasawa², Chin Piow Wong³, Nahoko Uchiyama⁴, Toshio Kaneda², Yukihiro Goda⁴, Hiroshi Morita¹

Affiliations

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan. y-hirasawa@hoshi.ac.jp.
² Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
³ Tokiwa Phytochemical Co., Ltd, 158, Kinoko, Sakura-shi, Chiba, 285-0801, Japan.
⁴ National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku Kawasaki, Kanagawa, 210-9501, Japan.

PMID: 34550553
DOI: 10.1007/s11418-021-01570-6

Abstract

Cliniatines A-C (1-3), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated from Clivia miniata (Lindl.) Bosse. The structures and absolute configurations of 1-3 were elucidated based on spectroscopic data and chemical correlation. Cliniatines A-C showed moderate inhibitory activity against acetylcholinesterase.

Keywords: Acetylcholinesterase; Amaryllidaceae alkaloid; Cliniatine A; Clivia miniata.

MeSH terms

Acetylcholinesterase
Amaryllidaceae Alkaloids* / pharmacology
Amaryllidaceae*
Cholinesterase Inhibitors / pharmacology
Plant Extracts

Substances

Amaryllidaceae Alkaloids
Cholinesterase Inhibitors
Plant Extracts
Acetylcholinesterase

Grants and funding

JP19K07152/japan society for the promotion of science