Improving rigor and reproducibility in nonhuman primate research

Eliza Bliss-Moreau; Rama R Amara; Elizabeth A Buffalo; Ricki J Colman; Monica E Embers; John H Morrison; Ellen E Quillen; Jonah B Sacha; Charles T Roberts; National Primate Research Center Consortium Rigor and Reproducibility Working Group

doi:10.1002/ajp.23331

Improving rigor and reproducibility in nonhuman primate research

Am J Primatol. 2021 Dec;83(12):e23331. doi: 10.1002/ajp.23331. Epub 2021 Sep 20.

Authors

Affiliations

¹ California National Primate Research Center, Davis, California, USA.
² Department of Psychology, University of California Davis, Davis, California, USA.
³ Division of Microbiology and Immunology, Yerkes National Primate Research Center, Atlanta, Georgia, USA.
⁴ Washington National Primate Research Center, Seattle, Washington, USA.
⁵ Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington, USA.
⁶ Wisconsin National Primate Research Center, Madison, Wisconsin, USA.
⁷ Department of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin, USA.
⁸ Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA.
⁹ Department of Neurology, University of California Davis, Davis, California, USA.
¹⁰ Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
¹¹ Divisions of Pathobiology and Immunology (JS) and Cardiometabolic Health (CR), Oregon National Primate Research Center, Beaverton, Oregon, USA.
¹² Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.

Abstract

Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Here, we discuss a number of approaches that collectively can contribute to enhanced rigor and reproducibility in NHP research.

Keywords: biomedical research; data sharing; nonhuman primates; preregistration; quality assurance.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Biomedical Research*
Disease Models, Animal
Primates*
Reproducibility of Results

Abstract

Publication types

MeSH terms

Grants and funding