Multiple immune function impairments in diabetic patients and their effects on COVID-19

Zhong-Hua Lu; Wei-Li Yu; Yun Sun

doi:10.12998/wjcc.v9.i24.6969

Multiple immune function impairments in diabetic patients and their effects on COVID-19

World J Clin Cases. 2021 Aug 26;9(24):6969-6978. doi: 10.12998/wjcc.v9.i24.6969.

Authors

Zhong-Hua Lu¹, Wei-Li Yu¹, Yun Sun²

Affiliations

¹ Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui Province, China.
² Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui Province, China. sunyun15@163.com.

Abstract

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2, poses a significant threat to public health worldwide, and diabetes is considered a risk factor for the rapid progression and poor prognosis of COVID-19. Limited immune function is a clinical feature of COVID-19 patients, and diabetes patients have defects in innate and adaptive immune functions, which may be an important reason for the rapid progression and poor prognosis of COVID-19 in patients with diabetes. We review the possible multiple effects of immune impairment in diabetic patients on the immune responses to COVID-19 to provide guidance for the diagnosis and treatment of diabetic patients with COVID-19.

Keywords: COVID-19; Diabetes; Immune function; SARS-CoV-2.

Publication types

Review