Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE

Wencui Yang; Xiaoning Li; Lin Zhao; Fengju Zhao

doi:10.1155/2021/8556965

Reversal of Radiotherapy Resistance of Ovarian Cancer Cell Strain CAOV3/R by Targeting lncRNA CRNDE

J Healthc Eng. 2021 Sep 8:2021:8556965. doi: 10.1155/2021/8556965. eCollection 2021.

Authors

Wencui Yang¹, Xiaoning Li², Lin Zhao¹, Fengju Zhao¹

Affiliations

¹ Department of Radiotherapy, Gansu Tumor Hospital, 730050 Lanzhou, Gansu, China.
² Gynecologic Oncology Department, Gansu Tumor Hospital, 730050 Lanzhou, Gansu, China.

Abstract

Radiotherapy resistance is one of the key factors of poor prognosis of ovarian cancer clinical treatment. The search for key targets of ovarian cancer radiotherapy resistance has become a high priority. Long noncoding RNA plays an important role in tumor development. However, the key lncRNA in ovarian cancer radiotherapy resistance is not identified. Our finding that lncRNA CRNDE is highly expressed in the radiotherapy resistance cell line CAOV3/R drew our attention. Therefore, in this study, we targeted lncRNA CRNDE to analyze whether it is a key factor of radiotherapy resistance in ovarian cancer. Ultimately, we found that silencing lncRNA CRNDE could reverse CAOV3/R radiotherapy resistance, which would be a boon to clinical treatment.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

Cell Line, Tumor
Cell Proliferation
Humans
Ovarian Neoplasms* / genetics
Ovarian Neoplasms* / radiotherapy
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding