Effect of Etoricoxib on miR-214 and inflammatory reaction in knee osteoarthritis patients

Weiwei He; Yujun Wu; Qianming Liu; Xiaoqiang Cheng; Jianjun Wu; Xueqing Han; Zheng Huang

Effect of Etoricoxib on miR-214 and inflammatory reaction in knee osteoarthritis patients

Am J Transl Res. 2021 Aug 15;13(8):9586-9592. eCollection 2021.

Authors

Weiwei He¹, Yujun Wu¹, Qianming Liu¹, Xiaoqiang Cheng¹, Jianjun Wu¹, Xueqing Han¹, Zheng Huang²

Affiliations

¹ Department of Hand and Foot Surgery, Traditional Medicine Hospital of Neijiang City Neijiang, Sichuan Province, China.
² The Second HospitaI, Cheeoo College of Medicine, Shandong University Jinan, Shandong Province, China.

PMID: 34540082
PMCID: PMC8430159

Abstract

Purpose: To explore the effect of Etoricoxib on serum miR-214 expression level and inflammatory reaction in patients with knee osteoarthritis.

Methods: 96 patients with knee osteoarthritis admitted to our hospital (January 2019 to January 2020) were selected. 48 patients in the control group received Celecoxib and 48 patients in the observation group received Etoricoxib. The treatment effect, knee function, inflammatory factor level, immune function, and serum miR-214 expression level of the two groups were compared. 6 months after treatment, the incidence of complications (deformities, deep infections and severe pain) between the two groups was compared.

Results: (1) The observation group had a higher total effective rate (93.75%) in comparison to the control group (72.92%) (P<0.05). (2) Before treatment, the serum miR-214 expression level of the two groups was basically the same (P>0.05). After treatment, the serum miR-214 expression level of the two groups decreased significantly, with a more marked decrease in the observation group (P<0.05). (3) Before treatment, the levels of IL-1β, TNF-α, and hs-CRP were not statistically different in the two groups (P>0.05). After treatment, IL-1β, TNF-α, and hs-CRP in both groups decreased, and the decrease in the observation group was significantly greater (P<0.05). (4) Before treatment, the levels of CD3⁺CD8⁺ and CD3⁺ were basically the same in both groups (P>0.05). After treatment, the levels of CD3⁺CD8⁺ and CD3⁺ in the two groups increased, and for the observation group, were significantly greater P<0.05. (5) The Lysholm score was higher in the observation group than it was in the control group (inter-group effect: F = 58.070, P<0.001), and the Lysholm score of both groups tended to increase with time (time effect: F = 145.900, P<0.001). Grouping and time showed an interactive effect (interactive effect: F = 8.646, P<0.001). 6 months after treatment, observation group showed a lower complication rate when compared to the control groupt (P<0.05).

Conclusion: Etoricoxib has a strong effect on patients with knee osteoarthritis. It can significantly reduce the expression of serum miR-214 and the level of inflammatory factors, and is worthy of clinical application.

Keywords: Etoricoxib; inflammatory reaction; knee osteoarthritis; miR-214.