KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer

Jing Chen; Cui-Cui Zhao; Fei-Ran Chen; Guo-Wei Feng; Fei Luo; Tao Jiang

doi:10.1155/2021/5572402

KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer

J Oncol. 2021 Sep 9:2021:5572402. doi: 10.1155/2021/5572402. eCollection 2021.

Authors

Jing Chen¹, Cui-Cui Zhao², Fei-Ran Chen³, Guo-Wei Feng³, Fei Luo⁴, Tao Jiang⁵

Affiliations

¹ Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.
² Department of VIP Ward, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.
³ Department of Genitourinary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, No. 24, Binshui Street, Hexi District, Tianjin 300060, China.
⁴ Department of Urology, Tianjin People's Hospital, No. 190, Jieyuan Road, Hongqiao District, Tianjin 300121, China.
⁵ Department of General Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, Dongcheng District, Beijing 100700, China.

Abstract

KIFs have been reported to play a critical role in a variety of tumors, and KIF20B is a protein in KFIs. In this research, KIF20B was highly expressed in the GEO database and our hospital's data, and high expression of KIF20B suggested poor prognosis. We detect the expression of KIF20B in pancreatic cancer and adjacent normal tissues using immunohistochemistry. Knockdown of KIF20B in pancreatic cancer cell lines, PANC-1 and BxPC-3 cells, inhibited cell proliferation which are detected by colony formation assays, CCK8, and western bolt of Ki-67 and PCNA. Xenograft assay showed a similar result in vivo. KIF20B is a potential therapeutic target in pancreatic cancer.