Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis

Rianne A A de Heus; Christophe Tzourio; Emily Jo Lynn Lee; Melissa Opozda; Andrew D Vincent; Kaarin J Anstey; Albert Hofman; Kazuomi Kario; Simona Lattanzi; Lenore J Launer; Yuan Ma; Rajiv Mahajan; Simon P Mooijaart; Michiaki Nagai; Ruth Peters; Deborah Turnbull; Yuichiro Yano; VARIABLE BRAIN Consortium; Jurgen A H R Claassen; Phillip J Tully

doi:10.1161/HYPERTENSIONAHA.121.17797

Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis

Hypertension. 2021 Nov;78(5):1478-1489. doi: 10.1161/HYPERTENSIONAHA.121.17797. Epub 2021 Sep 20.

Authors

Rianne A A de Heus¹, Christophe Tzourio², Emily Jo Lynn Lee³, Melissa Opozda^{3

4}, Andrew D Vincent³, Kaarin J Anstey^{5

6}, Albert Hofman⁷, Kazuomi Kario⁸, Simona Lattanzi⁹, Lenore J Launer¹⁰, Yuan Ma⁷, Rajiv Mahajan, Simon P Mooijaart^{11

12}, Michiaki Nagai¹³, Ruth Peters^{14

15}, Deborah Turnbull¹⁶, Yuichiro Yano^{17

18}; VARIABLE BRAIN Consortium; Jurgen A H R Claassen¹, Phillip J Tully³

Affiliations

¹ Radboud University Medical Center, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, the Netherlands (R.A.A.d.H., J.A.H.R.C.).
² Bordeaux Population Health, Univeristy of Bordeaux, Inserm, Team Healthy, UMR 1219, CHU Bordeaux, France (C.T.).
³ Adelaide Medical School (E.J.L.L., M.O., A.D.V., P.J.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.
⁴ Centre for Nutrition and Gastrointestinal Research (M.O.), South Australian Health and Medical Research Institute, Australia.
⁵ School of Psychology (K.J.A.), University of New South Wales, Sydney, Australia.
⁶ Neuroscience Research Australia (K.J.A.), University of New South Wales, Sydney, Australia.
⁷ Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA (A.H., Y.M.).
⁸ Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan (K.K.).
⁹ Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy (S.L.).
¹⁰ Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (L.J.L.).
¹¹ University of Adelaide, Lyell McEwin Hospital (R.M.), South Australian Health and Medical Research Institute, Australia.
¹² Department of Gerontology and Geriatrics, Leiden University Medical Center, Institute for Evidence-Based Medicine in Old Age, the Netherlands (S.P.M.).
¹³ Department of Cardiology, Hiroshima City Asa Hospital, Japan (M.N.).
¹⁴ Neuroscience Research Australia (R.P.), University of New South Wales, Sydney, Australia.
¹⁵ Imperial College London, United Kingdom (R.P.).
¹⁶ School of Psychology (D.T.), Freemasons Centre for Male Health and Wellbeing, The University of Adelaide, Australia.
¹⁷ Yokohama City University Center for Novel and Exploratory Clinical Trials, Yokohama City University Hospital, Japan (Y.Y.).
¹⁸ The Department of Family Medicine and Community Health, Duke University, Durham, NC (Y.Y.).

Abstract

[Figure: see text].

Keywords: Alzheimer disease; blood pressure; cerebrovascular disorders; dementia; hemodynamics; meta-analysis; stroke.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Blood Pressure / physiology*
Cognitive Dysfunction / etiology*
Dementia / etiology*
Humans
Hypertension / complications*
Risk