Multiple fluorescence response behaviors towards antibiotics and bacteria based on a highly stable Cd-MOF

Quan-Quan Li; Ming-Jie Wen; Yu-Sen Zhang; Zi-Sheng Guo; Xue Bai; Jin-Xi Song; Ping Liu; Yao-Yu Wang; Jian-Li Li

doi:10.1016/j.jhazmat.2021.127132

Multiple fluorescence response behaviors towards antibiotics and bacteria based on a highly stable Cd-MOF

J Hazard Mater. 2022 Feb 5;423(Pt B):127132. doi: 10.1016/j.jhazmat.2021.127132. Epub 2021 Sep 11.

Authors

Quan-Quan Li¹, Ming-Jie Wen², Yu-Sen Zhang², Zi-Sheng Guo³, Xue Bai⁴, Jin-Xi Song⁵, Ping Liu⁶, Yao-Yu Wang², Jian-Li Li⁷

Affiliations

¹ Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China; Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity, College of Urban and Environmental Sciences, Northwest University, Xi'an 710127, China.
² Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
³ Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China; Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an 710069, PR China.
⁴ Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China; School of Chemical Engineering, Northwest University, Xi'an 710069, PR China.
⁵ Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity, College of Urban and Environmental Sciences, Northwest University, Xi'an 710127, China. Electronic address: jinxisong@nwu.edu.cn.
⁶ Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China. Electronic address: liuping@nwu.edu.cn.
⁷ Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China. Electronic address: lijianli@nwu.edu.cn.

PMID: 34537652
DOI: 10.1016/j.jhazmat.2021.127132

Abstract

The abuse of antibiotics has triggered the rise of drug-resistance bacteria, which has seriously threatened public health globally. As a result, carrying out efficient and accurate antibiotic and bacteria identification are quite significant but challenge. Herein, an unprecedented Cd-MOF-based sensor, [CdL]_n [1, H₂L = 4-(2-methyl-1H-benzo[d]imidazol-1-yl) isophthalic acid] with multiple fluorescence response behaviours towards antibiotics and bacteria was developed. Single-crystal X-ray diffraction revealed that 1 is a mesomeric 2D bilayer, which is comprised of two opposite chiral mono-layers, each assembled by left-handed or right-handed helixes. More interestingly, 1 represented multiplex detection capability towards antibiotics and bacteria through two detection behaviors: toward nitro-antibiotics and chlortetracycline (CTC) via fluorescent quenching, while toward Staphylococcus albus (S. albus) via fluorescent enhancement. Remarkably, 1 showed a low limit of detection (LOD, 47 CFU/mL) accompanied with specificity in the detection of S. albus compared to other bacteria, such as Staphylococcus aureus, Acinetobacter baumannii, Klebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli. In addition, the LOD could reach to ppm level for nitro-antibiotics and CTC. Moreover, the practical application of 1 was further reinforced through the detection of nitro-antibiotics and CTC, as well as S. albus in fetal calf serum and river water.

Keywords: Chlortetracycline; Fluorescent sensor; Metal-Organic Framework; Nitro-antibiotics; Staphylococcus albus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / therapeutic use
Cadmium*
Microbial Sensitivity Tests
Staphylococcus aureus
Staphylococcus epidermidis

Substances

Anti-Bacterial Agents
Cadmium