Extracellular Matrix Enzymes and Immune Cell Biology

Meagan McMahon; Siying Ye; Jess Pedrina; Daniel Dlugolenski; John Stambas

doi:10.3389/fmolb.2021.703868

Extracellular Matrix Enzymes and Immune Cell Biology

Front Mol Biosci. 2021 Aug 30:8:703868. doi: 10.3389/fmolb.2021.703868. eCollection 2021.

Authors

Meagan McMahon¹, Siying Ye¹, Jess Pedrina¹, Daniel Dlugolenski¹, John Stambas¹

Affiliation

¹ Faculty of Health, School of Medicine, Deakin University, Geelong, VIC, Australia.

Abstract

Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.

Keywords: a disintegrin and metalloproteinases; a disintegrin and metalloproteinases with thombospondin-1 motifs; extracellular matrix; immunity; metalloproteinases.

Publication types

Review