Characterization of Crohn's disease patients in Egypt: Risk factors for postoperative recurrence (A cohort study)

Shimaa Kamel; Mohamed Sakr; Waleed Hamed; Mohamed Eltabbakh; Ahmed Sherief; Heba Rashad; Yasser Elghamrini; Ahmed Elbaz

doi:10.1016/j.amsu.2021.102781

Characterization of Crohn's disease patients in Egypt: Risk factors for postoperative recurrence (A cohort study)

Ann Med Surg (Lond). 2021 Sep 6:69:102781. doi: 10.1016/j.amsu.2021.102781. eCollection 2021 Sep.

Authors

Shimaa Kamel¹, Mohamed Sakr¹, Waleed Hamed¹, Mohamed Eltabbakh¹, Ahmed Sherief¹, Heba Rashad¹, Yasser Elghamrini², Ahmed Elbaz¹

Affiliations

¹ Department of Tropical Medicine, Gastroenterology, and Hepatology, Ain Shams University, Abbasiya, Cairo, Egypt.
² Department of General Surgery, Ain Shams University, Abbasiya, Cairo, Egypt.

Abstract

Background: The aim of study to identify the characterizations of Crohn's disease in Egyptian patients and to determine its predictors for postoperative recurrence.

Methods: We conducted a retrospective observational cohort study on 15 patients diagnosed as Crohn's disease with surgical interventions. Different characteristics of studied patients were analyzed to determine the risk factors for postoperative recurrence such as age at diagnosis, gender, smoking, main presenting symptom, Montreal classification, perianal disease, laboratory findings and protocol of management including surgical characteristics like age at operation, surgical indication, preoperative medication, surgical approach, and operative findings.

Results: Nine of the studied patients (60%) suffered from clinical postoperative recurrence with mean duration of 23.5 ± 40.6 months. In comparison the demographic, clinical, operative, and medical treatment data between patients with postoperative recurrence of Crohn's disease and those without recurrence, age at diagnosis (mean age 42.9 years) and age at operation (mean 44.7 years) were found statistically significant in postoperative recurrence group (p-value = 0.001). According to Montreal classification of Crohn's disease, patients >40 years were significantly found in postoperative recurrence group, while patients between 17 and 40 years were significantly found in postoperative non-recurrence group (p-value=0.007) and ileal location of Crohn's disease was found significantly in postoperative recurrent group (p-value=0.044). Postoperative biological therapy significantly decreased the incidence of postoperative recurrence in the current study (p-value= 0.041).

Conclusions: Age at diagnosis, age at operation, ileal location of Crohn's disease can significantly predict postoperative recurrence. Also, postoperative biological therapy can significantly decrease the incidence of postoperative recurrence.

Keywords: Biological therapy; Characterizations; Crohn's disease; Montreal classification; Postoperative recurrence.