This study examined how psychological distance, both social and temporal, can be leveraged in prosocial health behavior messages to mitigate perceived psychological reactance. Following the construal level and psychological reactance theories, we conducted a 2 × 2 between-subjects factorial design (N = 245), which manipulated naturalistic messages regarding a prosocial communications campaign. Structural equation modeling showed that far temporal distance combined with far social distance could significantly reduce threat to freedom and therefore positively affect attitudes and behavioral intentions toward prosocial health topics. The effect of social distance was found not significant, differing from past findings. Further, intertwined and parallel psychological reactance models were tested and discussed. We suggest the need for more psychological reactance research, particularly examining prosocial health behavior. Strategies for practical persuasion strategies in prosocial messages are proposed.