A new adaptive weighting method [delay-and-sum-to-delay-standard-deviation factor (DASDSF)] combined with minimum variance (MV) beamforming is introduced in photoacoustic imaging (PAI). Existing MV-based beamformers improve photoacoustic image quality in terms of achieving narrow main lobes and, thus, improving spatial resolution. But, the beamformers give a strong side-lobe signal strength that greatly degrades the reconstructed image contrast. As a feedback weighting factor, DASDSF addresses the persisting side-lobe issue present in MV-beamformed images, i.e., our proposed method is robust against reduction in noises as well as side lobes, and it outperforms MV and MV combined with coherence factor beamformers. Validation studies-being carried out both in numerical simulation and experiments employing a low-cost (16 elements) linear transducer array in a home-built PAI system-demonstrate an excellent performance of the proposed weighting approach in improving SNR, while reducing main-lobe width (i.e., FWHM) and side-lobe signal strength. The study demonstrates that the proposed algorithm holds promise for development of a cost-effective PAI system using a low-cost linear transducer (∼16 elements against ∼128 generally used).