Regioselective Monoborylation of Spirocyclobutenes

Org Lett. 2021 Oct 1;23(19):7434-7438. doi: 10.1021/acs.orglett.1c02645. Epub 2021 Sep 15.

Abstract

We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol. The boryl moiety provides a synthetic handled for further functionalization, allowing access to a wide array of spirocyclic building blocks from a common intermediate.

Publication types

  • Research Support, Non-U.S. Gov't