Data on effect of Tempeh Fermentation on patients with type II diabetes

Hui-Kan Su; Ming-Hsien Tsai; How-Ran Chao; Mei-Li Wu; Jian-He Lu

doi:10.1016/j.dib.2021.107310

Data on effect of Tempeh Fermentation on patients with type II diabetes

Data Brief. 2021 Sep 4:38:107310. doi: 10.1016/j.dib.2021.107310. eCollection 2021 Oct.

Authors

Hui-Kan Su^{1

2}, Ming-Hsien Tsai³, How-Ran Chao^{4

5}, Mei-Li Wu¹, Jian-He Lu⁴

Affiliations

¹ Department of Food Science, National Pingtung University of Science and Technology, Pingtung County 912, Taiwan.
² Department of Pathology Laboratory, Kaohsiung Veterans General Hospital Pingtung Branch, Pingtung County 912, Taiwan.
³ Department of Child Care, College of Humanities and Social Sciences, National Pingtung University of Science and Technology, Pingtung County 912, Taiwan.
⁴ Emerging Compounds Research Center, Department of Environmental Science and Engineering, College of Engineering, National Pingtung University of Science and Technology, Pingtung County 912, Taiwan.
⁵ Institute of Food Safety Management, College of Agriculture, National Pingtung University of Science and Technology, Neipu, Pingtung County 912, Taiwan.

Abstract

Type II diabetes (T2D) arises through insulin resistance and a progressive decrease in insulin secretion, which may be partly related to pancreatic beta-cell function decline, obesity, and eventual hyperglycemia [1]. The first line for managing hyperglycemia in patients with T2D includes lifestyle modifications and metformin monotherapy. However, many patients still showed poor glycemic control due to progressive deterioration during the course of T2D [2, 3]. On streptozotocin-induced T2D rats, tempeh fermentation has been shown to be a potentially beneficial dietary supplement for abnormal carbohydrate metabolism [4]. This study was a prospective open-label clinical trial. The data were collected from Kaohsiung Veterans General Hospital Pingtung Branch, Taiwan from August 2018 to July 2019. 35 eligible T2D participants with a mean age of 57.91 ± 10.17 years were enrolled. After taking 2 g tempeh capsules daily for a period of 3 months, the levels of HbA1C and triglyceride were noticeably decreased in the participants. A regression analysis revealed that cholesterol concentration had a significant positive correlation with the concentrations of LDL, but triglyceride concentration had a significant negative correlation with the concentrations of HDL in the pre- and the post-tempeh treatment.

Keywords: Glycated hemoglobin A1C; Tempeh Fermentation; Triglyceride; Type II diabetes.