Electrochemical sulfonylation of enamides with sodium sulfinates to access β-amidovinyl sulfones

Org Biomol Chem. 2021 Oct 6;19(38):8295-8300. doi: 10.1039/d1ob01485d.

Abstract

The electrochemical sulfonylation of enamides with sodium sulfinates was developed in an undivided cell in constant current mode, leading to the formation of β-amidovinyl sulfones in moderate to good yields. The catalyst-, electrolyte- and oxidant-free protocol features good functional group tolerance and employs electric current as a green oxidant. Mechanistic insights into the reaction indicate that the reaction may proceed via a radical mechanism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Catalysis
  • Ions
  • Oxidants
  • Sodium*
  • Sulfones*

Substances

  • Ions
  • Oxidants
  • Sulfones
  • Sodium