Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson

Hui-Chi Huang; Chun-Hsiang Lin; Ching-Chuan Kuo; Ming-Der Wu; Ming-Jen Cheng; Jih-Jung Chen; Che-Yi Chao; Guan-Jhong Huang; Yueh-Hsiung Kuo

doi:10.1080/14786419.2021.1948042

Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson

Nat Prod Res. 2023 Jan;37(1):47-55. doi: 10.1080/14786419.2021.1948042. Epub 2021 Sep 14.

Authors

Hui-Chi Huang^{1

2}, Chun-Hsiang Lin³, Ching-Chuan Kuo⁴, Ming-Der Wu⁵, Ming-Jen Cheng⁵, Jih-Jung Chen⁶, Che-Yi Chao⁷, Guan-Jhong Huang¹, Yueh-Hsiung Kuo^{1

8

9}

Affiliations

¹ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
² Master Program for Food and Drug Safety, China Medical University, Taichung, Taiwan.
³ Department of Chemistry, National Taiwan University, Taipei, Taiwan.
⁴ Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
⁵ Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
⁶ Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan.
⁷ Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
⁸ Department of Biotechnology, Asia University, Taichung, Taiwan.
⁹ Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.

PMID: 34519597
DOI: 10.1080/14786419.2021.1948042

Abstract

Two new chromones named cnidimol G (1) and cnidimol H (2), one new coumarin, 7-methoxy-8-(3-methoxy-3-methyl-2-oxobutyl)coumarin (3), and twenty known compounds were isolated from MeOH extract of the fruit of Cnidium monnieri (L.) Cusson. The structures of compounds were elucidated by extensive spectroscopic analyses including 1 D and 2 D NMR, HRESIMS, IR and UV. Anti-inflammatory activity of the selected isolated compounds were evaluated. Compounds 1 and 8 exhibited inhibitory activities against nitric oxide production.

Keywords: Cnidium monnieri (L.) Cusson; anti-inflammatory activity; chromones; coumarin.

MeSH terms

Chromones / analysis
Chromones / pharmacology
Cnidium* / chemistry
Coumarins / chemistry
Fruit* / chemistry
Plant Extracts / chemistry

Substances

Chromones
Plant Extracts
Coumarins