Mitochondrial disease: Replace or edit?

Science. 2021 Sep 10;373(6560):1200-1201. doi: 10.1126/science.abg0491. Epub 2021 Sep 9.

Authors

Eli Y Adashi¹, Donald S Rubenstein², Jim A Mossman³, Eric A Schon⁴, I Glenn Cohen⁵

Affiliations

¹ Department of Medical Science, Brown University, Providence, RI, USA.
² Prisma Health-Upstate, Greenville, SC, USA.
³ Aspen Neuroscience, San Diego, CA, USA.
⁴ Department of Neurology, and Department of Genetics and Development, Columbia University, New York, NY.
⁵ Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard Law School, Harvard University, Cambridge, MA, USA.

PMID: 34516801
DOI: 10.1126/science.abg0491

Abstract

Questions over mitochondrial replacement suggest a role for mitochondrial DNA editing.

MeSH terms

Animals
DNA, Mitochondrial / genetics*
Gene Editing*
Genetic Therapy / methods*
Humans
Mitochondrial Diseases / genetics*
Mitochondrial Diseases / therapy*
Mitochondrial Replacement Therapy*

Substances

DNA, Mitochondrial