Association of gene polymorphisms with women urinary incontinence

Povilas Aniulis; Aurelija Podlipskyte; Alina Smalinskiene; Rosita Aniuliene; Mindaugas Jievaltas

doi:10.1515/med-2021-0332

Association of gene polymorphisms with women urinary incontinence

Open Med (Wars). 2021 Aug 25;16(1):1190-1197. doi: 10.1515/med-2021-0332. eCollection 2021.

Authors

Povilas Aniulis¹, Aurelija Podlipskyte², Alina Smalinskiene³, Rosita Aniuliene⁴, Mindaugas Jievaltas¹

Affiliations

¹ Urology Clinic, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, Kaunas LT-44307, Lithuania.
² Laboratory of Behavioral Medicine, Neuroscience Institute, Lithuanian University of Health Sciences, Palanga LT-00135, Lithuania.
³ Institute of Biology Systems And Genetic Research, Lithuanian University Of Health Sciences, Kaunas LT-44307, Lithuania.
⁴ Obstetrics And Gynecology Clinic, Medical Academy, Lithuanian University of Health Sciences, Kaunas LT-44307, Lithuania.

Abstract

Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor HTR2A T102C and beta 3-adrenergic receptor ADRB3 Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group - 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of HTR2A T102C gene polymorphism's minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, p = 0.007 and CC-57.6 vs 31.1%, p = 0.015). The ADRB3 Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11-8.43; p = 0.030) and allele C (OR = 2.53, 95% CI: 1.16-5.53; p = 0.020) were risk factors for development of Urge UI. We conclude that HTR2A T102C gene polymorphism affected the development of Urge UI.

Keywords: ADRB3; HTR2A; UI; gene polymorphism; serotonin receptor 2A.