Primary Cilia-Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma

Minghao Li; Jiaxun Zhang; Haonan Zhou; Rong Xiang

doi:10.3389/fonc.2021.718995

Primary Cilia-Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma

Front Oncol. 2021 Aug 26:11:718995. doi: 10.3389/fonc.2021.718995. eCollection 2021.

Authors

Minghao Li¹, Jiaxun Zhang¹, Haonan Zhou², Rong Xiang^{2

3}

Affiliations

¹ Xiangya School of Medicine, Central South University, Changsha, China.
² School of Life Sciences, Central South University, Changsha, China.
³ Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha, China.

Abstract

As microtubule-based structures, primary cilia are typically present on the cells during the G0 or G1-S/G2 phase of the cell cycle and are closely related to the development of the central nervous system. The presence or absence of this special organelle may regulate the central nervous system tumorigenesis (e.g., glioblastoma) and several degenerative diseases. Additionally, the development of primary cilia can be regulated by several pathways. Conversely, primary cilia are able to regulate a few signaling transduction pathways. Therefore, development of the central nervous system tumors in conjunction with abnormal cilia can be regulated by up- or downregulation of the pathways related to cilia and ciliogenesis. Here, we review some pathways related to ciliogenesis and tumorigenesis, aiming to provide a potential target for developing new therapies at genetic and molecular levels.

Keywords: CCRK; HDAC6; LPAR1; PCM1; glioblastoma; primary cilia; sonic hedgehog.

Publication types

Review