Specific detection of glucose by an optical weak measurement sensor

Yang Xu; Lixuan Shi; Tian Guan; Cuixia Guo; Suyi Zhong; Chongqi Zhou; Hailong Zhang; Zhangyan Li; Xinhui Xing; Yanhong Ji; Wenyue Xie; Le Liu; Yonghong He

doi:10.1364/BOE.422199

Specific detection of glucose by an optical weak measurement sensor

Biomed Opt Express. 2021 Jul 21;12(8):5128-5138. doi: 10.1364/BOE.422199. eCollection 2021 Aug 1.

Authors

Yang Xu^{1

2

3

4}, Lixuan Shi^{1

5

6}, Tian Guan^{1

7}, Cuixia Guo⁸, Suyi Zhong^{1

7}, Chongqi Zhou^{1

5}, Hailong Zhang¹, Zhangyan Li^{1

5}, Xinhui Xing², Yanhong Ji⁹, Wenyue Xie^{3

10}, Le Liu^{6

11}, Yonghong He^{1

2

12}

Affiliations

¹ Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
² Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
³ Peking Univ, ShenZhen Hosp, Dept Clin Lab, Shenzhen, China.
⁴ Y. Xu and L. Shi contributed equally to this work.
⁵ Department of Physics, Tsinghua University, Beijing 100084, China.
⁶ Institute of Materials Research, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
⁷ School of Medicine, Tsinghua University, Beijing 100084, China.
⁸ School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350108, China.
⁹ School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006, China.
¹⁰ xwy2114@163.com.
¹¹ liu.le@sz.tsinghua.edu.cn.
¹² heyh@sz.tsinghua.edu.cn.

Abstract

Diabetes is an important public health problem and finding quick testing methods with high accuracy, reliability, and convenience are important to control the blood glucose of diabetic patients. In this study, a sensor based on a weak measurement scheme was developed for the specific detection of glucose for the first time. The detection of glucose using the proposed method was completed by the high sensitivity and resolution of the weak measurement based on optical rotation detection, as well as the change in the optical rotation before and after the specific oxidation of glucose. The resolution of the as-obtained glucose sensor was around 2.71×10^-3 g/L (1.50×10^-2 mmol/L), and the detection range was 0-11 g/L (0-61 mmol/L).