Adverse Cardiovascular Effects of Anti-COVID-19 Drugs

Dongling Liu; Xiang Zeng; Zufeng Ding; Fenghua Lv; Jawahar L Mehta; Xianwei Wang

doi:10.3389/fphar.2021.699949

Adverse Cardiovascular Effects of Anti-COVID-19 Drugs

Front Pharmacol. 2021 Aug 25:12:699949. doi: 10.3389/fphar.2021.699949. eCollection 2021.

Authors

Dongling Liu¹, Xiang Zeng², Zufeng Ding³, Fenghua Lv⁴, Jawahar L Mehta³, Xianwei Wang^{1

4}

Affiliations

¹ Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.
² Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, China.
³ Division of Cardiology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, United States.
⁴ Department of Cardiology, Xinxiang Medical University First Affiliated Hospital, Weihui, China.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 infection is the cause of the ongoing global pandemic. Mortality from COVID-19 infection is particularly high in patients with cardiovascular diseases. In addition, COVID-19 patients with preexisting cardiovascular comorbidities have a higher risk of death. Main cardiovascular complications of COVID-19 are myocardial infarction, myocarditis, acute myocardial injury, arrhythmias, heart failure, stroke, and venous thromboembolism. Therapeutic interventions in terms of drugs for COVID-19 have many cardiac adverse effects. Here, we review the relative therapeutic efficacy and adverse effects of anti-COVID-19 drugs.

Keywords: COVID-19; SARS-CoV-2; anti-COVID-19 therapy; cardiovascular complications; inflammation.

Publication types

Review